| 2. Round | 20/08/2021 | Rot-Weiss Essen | - | SV 19 Straelen | 1:4 | ||||
| 3. Round | 24/08/2021 | Bonner SC | - | SV 19 Straelen | 1:3 | ||||
| 4. Round | 28/08/2021 | SV 19 Straelen | - | Wuppertaler SV | 1:4 | ||||
| 11. Round | 09/10/2021 | Rot-Weiß Oberhausen | - | SV 19 Straelen | 0:0 | ||||
| 12. Round | 16/10/2021 | SV 19 Straelen | - | KFC Uerdingen 05 | 2:0 | ||||
| 13. Round | 23/10/2021 | SC Wiedenbrück | - | SV 19 Straelen | 2:0 | ||||
| 14. Round | 30/10/2021 | SV 19 Straelen | - | 1. FC Köln II | 1:2 | ||||
| 15. Round | 05/11/2021 | Alemannia Aachen | - | SV 19 Straelen | 5:3 | ||||
| 35. Round | 23/04/2022 | Bor. Mönchengladbach II | - | SV 19 Straelen | 2:1 | ||||
| 36. Round | 30/04/2022 | SV 19 Straelen | - | Sportfreunde Lotte | 2:1 |  |
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| 37. Round | 07/05/2022 | FC Wegberg-Beeck | - | SV 19 Straelen | 2:3 | ||||
| 38. Round | 14/05/2022 | SV 19 Straelen | - | SV Rödinghausen | 1:4 |
Germany