| 9. Round | 25/09/2021 | TSV Schott Mainz | - | SV 07 Elversberg | 3:3 | ||||
| 10. Round | 28/09/2021 | Kickers Offenbach | - | TSV Schott Mainz | 0:1 | ||||
| 15. Round | 26/10/2021 | TSV Schott Mainz | - | FC-Astoria Walldorf | 3:1 | ||||
| 18. Round | 13/11/2021 | TSV Schott Mainz | - | FK Pirmasens | 0:1 | ||||
| 19. Round | 20/11/2021 | Bahlinger SC | - | TSV Schott Mainz | 1:0 | ||||
| 20. Round | 27/11/2021 | TSG Balingen | - | TSV Schott Mainz | 4:0 | ||||
| 22. Round | 11/12/2021 | FC Gießen | - | TSV Schott Mainz | 3:0 | ||||
| 21. Round | 15/12/2021 | TSV Schott Mainz | - | VfR Aalen | 2:0 | ||||
| 23. Round | 18/12/2021 | TSV Schott Mainz | - | TSV Steinbach Haiger | 3:3 | ||||
| 24. Round | 13/02/2022 | SG Sonnenhof Großaspach | - | TSV Schott Mainz | 0:1 |  |
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| 25. Round | 19/02/2022 | TSV Schott Mainz | - | VfB Stuttgart II | 2:1 | ||||
| 26. Round | 26/02/2022 | FSV Frankfurt | - | TSV Schott Mainz | 2:2 | ||||
| 27. Round | 05/03/2022 | TSV Schott Mainz | - | FC 08 Homburg | 0:3 | ||||
| 35. Round | 23/04/2022 | TSV Schott Mainz | - | 1. FSV Mainz 05 II | 0:0 | ||||
| 37. Round | 07/05/2022 | FK Pirmasens | - | TSV Schott Mainz | 2:1 |
Germany