1. Round | 15/08/2021 | FC Schalke 04 II | - | 1. FC Köln II | 1:2 | ||||
2. Round | 20/08/2021 | 1. FC Köln II | - | SV Lippstadt 08 | 3:1 | ||||
3. Round | 25/08/2021 | Rot-Weiß Oberhausen | - | 1. FC Köln II | 1:0 | ||||
4. Round | 28/08/2021 | 1. FC Köln II | - | KFC Uerdingen 05 | 8:2 | ||||
6. Round | 10/09/2021 | 1. FC Köln II | - | Bonner SC | 3:2 | ||||
9. Round | 25/09/2021 | 1. FC Köln II | - | Sportfreunde Lotte | 4:0 | ||||
5. Round | 28/09/2021 | SC Wiedenbrück | - | 1. FC Köln II | 2:0 | ||||
10. Round | 01/10/2021 | FC Wegberg-Beeck | - | 1. FC Köln II | 0:1 | ||||
12. Round | 15/10/2021 | Rot Weiss Ahlen | - | 1. FC Köln II | 2:6 | ||||
29. Round | 12/03/2022 | 1. FC Köln II | - | FC Wegberg-Beeck | 4:1 | ||||
31. Round | 26/03/2022 | 1. FC Köln II | - | Rot Weiss Ahlen | 6:1 | ||||
32. Round | 01/04/2022 | Rot-Weiss Essen | - | 1. FC Köln II | 2:0 | ||||
26. Round | 20/04/2022 | Alemannia Aachen | - | 1. FC Köln II | 1:1 | ||||
35. Round | 23/04/2022 | 1. FC Köln II | - | Fortuna Köln | 2:2 | ||||
36. Round | 29/04/2022 | Fortuna Düsseldorf II | - | 1. FC Köln II | 0:1 | ||||
37. Round | 07/05/2022 | 1. FC Köln II | - | VfB Homberg | 2:1 | ||||
38. Round | 14/05/2022 | Preußen Münster | - | 1. FC Köln II | 2:1 |