| 1. Round | 23/07/2022 | SV Rödinghausen | - | 1. FC Köln II | 5:0 |  |
|||
| 3. Round | 07/08/2022 | 1. FC Kaan-Marienborn | - | 1. FC Köln II | 1:1 | ||||
| 5. Round | 21/08/2022 | 1. FC Düren | - | 1. FC Köln II | 3:2 | ||||
| 8. Round | 11/09/2022 | 1. FC Köln II | - | Wuppertaler SV | 2:1 | ||||
| 9. Round | 18/09/2022 | Rot Weiss Ahlen | - | 1. FC Köln II | 1:3 |  |
|||
| 11. Round | 08/10/2022 | SC Wiedenbrück | - | 1. FC Köln II | 2:0 | ||||
| 13. Round | 21/10/2022 | Alemannia Aachen | - | 1. FC Köln II | 3:1 | ||||
| 15. Round | 05/11/2022 | SV 19 Straelen | - | 1. FC Köln II | 0:0 | ||||
| 16. Round | 10/11/2022 | Fortuna Köln | - | 1. FC Köln II | 2:2 |  |
|||
| 17. Round | 19/11/2022 | 1. FC Köln II | - | SV Lippstadt 08 | 0:0 | ||||
| 18. Round | 26/11/2022 | 1. FC Köln II | - | SV Rödinghausen | 2:2 | ||||
| 19. Round | 02/12/2022 | FC Schalke 04 II | - | 1. FC Köln II | 5:0 |
Germany