| 2. Round | 21/08/2021 | SC Wiedenbrück | - | Rot-Weiß Oberhausen | 1:0 | ||||
| 3. Round | 25/08/2021 | KFC Uerdingen 05 | - | SC Wiedenbrück | 2:3 | ||||
| 5. Round | 28/09/2021 | SC Wiedenbrück | - | 1. FC Köln II | 2:0 | ||||
| 12. Round | 16/10/2021 | Rot-Weiss Essen | - | SC Wiedenbrück | 0:0 | ||||
| 15. Round | 06/11/2021 | SC Wiedenbrück | - | Fortuna Köln | 0:1 | ||||
| 22. Round | 22/01/2022 | SC Wiedenbrück | - | KFC Uerdingen 05 | 5:1 | ||||
| 20. Round | 15/02/2022 | SC Wiedenbrück | - | SV Lippstadt 08 | 2:2 |
Germany