| 1. Round | 14/08/2021 | VfB Homberg | - | Bor. Mönchengladbach II | 0:2 | ||||
| 2. Round | 21/08/2021 | Sportfreunde Lotte | - | VfB Homberg | 2:0 | ||||
| 3. Round | 25/08/2021 | VfB Homberg | - | FC Wegberg-Beeck | 1:1 | ||||
| 4. Round | 28/08/2021 | SV Rödinghausen | - | VfB Homberg | 0:1 | ||||
| 5. Round | 04/09/2021 | VfB Homberg | - | Rot Weiss Ahlen | 1:2 | ||||
| 14. Round | 30/10/2021 | VfB Homberg | - | SV Lippstadt 08 | 3:2 |  |
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| 15. Round | 06/11/2021 | Rot-Weiß Oberhausen | - | VfB Homberg | 3:1 | ||||
| 16. Round | 13/11/2021 | VfB Homberg | - | KFC Uerdingen 05 | 1:1 |  |
Germany