| 2. Round | 21/08/2021 | FC Gießen | - | 1. FSV Mainz 05 II | 0:1 | ||||
| 3. Round | 25/08/2021 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 2:1 | ||||
| 4. Round | 29/08/2021 | SG Sonnenhof Großaspach | - | 1. FSV Mainz 05 II | 1:3 | ||||
| 7. Round | 14/09/2021 | 1. FSV Mainz 05 II | - | FC 08 Homburg | 1:2 | ||||
| 8. Round | 18/09/2021 | SV 07 Elversberg | - | 1. FSV Mainz 05 II | 5:0 |  |
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| 10. Round | 28/09/2021 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 0:2 | ||||
| 11. Round | 02/10/2021 | 1. FSV Mainz 05 II | - | Rot-Weiß Koblenz | 2:1 |
Luxembourg
Italy