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| 1st(1st leg) | Karlsruher SC | - | Bor. Mönchengladbach | 1:1 | ||
| 2nd (2nd leg) | Bor. Mönchengladbach | - | Karlsruher SC | 4:3 pso | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: Bor. Mönchengladbach | ||||
| 1st(1st leg) | VfB Stuttgart | - | VfB Lübeck | 7:0 | ||
| 2nd (2nd leg) | VfB Lübeck | - | VfB Stuttgart | 0:4 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: VfB Stuttgart | ||||
| 1st(1st leg) | Bayern München | - | 1. FC Kaiserslautern | 0:0 | ||
| 2nd (2nd leg) | 1. FC Kaiserslautern | - | Bayern München | 1:0 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: 1. FC Kaiserslautern | ||||
| 1st(1st leg) | FC St. Pauli | - | Bayer Leverkusen | 0:2 | ||
| 2nd (2nd leg) | Bayer Leverkusen | - | FC St. Pauli | 1:3 pso | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: FC St. Pauli | ||||
| 1st(1st leg) | Blau-Weiß 90 Berlin | - | VfL Wolfsburg | 4:1 | ||
| 2nd (2nd leg) | VfL Wolfsburg | - | Blau-Weiß 90 Berlin | 2:1 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: Blau-Weiß 90 Berlin | ||||
| 1st(1st leg) | Freiburger FC | - | Werder Bremen | 1:0 | ||
| 2nd (2nd leg) | Werder Bremen | - | Freiburger FC | 1:2 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: Freiburger FC | ||||
| 1st(1st leg) | FC Schalke 04 | - | Eintracht Frankfurt | 3:1 | ||
| 2nd (2nd leg) | Eintracht Frankfurt | - | FC Schalke 04 | 1:3 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: FC Schalke 04 | ||||
| 1st(1st leg) | 1. FC Saarbrücken | - | SG 99 Andernach | 3:3 | ||
| 2nd (2nd leg) | SG 99 Andernach | - | 1. FC Saarbrücken | 1:4 | ||
| 1st(1st leg): 14/06/1981 | 2nd (2nd leg): 21/06/1981 | Winner: 1. FC Saarbrücken | ||||
