1st(1st leg) RSC Anderlecht - Dinamo Kiev 1:1 (1:0)
2nd (2nd leg) Dinamo Kiev - RSC Anderlecht 2:1 (0:0)
1st(1st leg): 06/11/2018 18:30 2nd (2nd leg): 27/11/2018 15:00 Winner: Dinamo Kiev
1st(1st leg) FK Astana - Dinamo Zagreb 1:1 (1:0)
2nd (2nd leg) Dinamo Zagreb - FK Astana 3:1 (2:0)
1st(1st leg): 07/11/2018 05:00 2nd (2nd leg): 27/11/2018 12:30 Winner: Dinamo Zagreb
1st(1st leg) Gabala FK - Hertha BSC 1:3 (0:0)
2nd (2nd leg) Hertha BSC - Gabala FK 1:0 (1:0)
1st(1st leg): 07/11/2018 13:00 2nd (2nd leg): 28/11/2018 12:00 Winner: Hertha BSC
1st(1st leg) Altınordu FSG - Montpellier HSC 2:4 (1:2)
2nd (2nd leg) Montpellier HSC - Altınordu FSG 1:0 (0:0)
1st(1st leg): 07/11/2018 15:00 2nd (2nd leg): 28/11/2018 14:00 Winner: Montpellier HSC
1st(1st leg) PAOK Saloniki - FK Minsk 2:1 (1:1)
2nd (2nd leg) FK Minsk - PAOK Saloniki 0:1 (0:0)
1st(1st leg): 07/11/2018 15:00 2nd (2nd leg): 28/11/2018 11:00 Winner: PAOK Saloniki
1st(1st leg) Sigma Olomouc - Maccabi Tel Aviv 1:1 (0:0)
2nd (2nd leg) Maccabi Tel Aviv - Sigma Olomouc 2:2 (0:0)
1st(1st leg): 07/11/2018 15:00 2nd (2nd leg): 28/11/2018 15:00 Winner: Sigma Olomouc
1st(1st leg) IF Elfsborg - Chelsea FC 0:3 (0:1)
2nd (2nd leg) Chelsea FC - IF Elfsborg 6:0 (4:0)
1st(1st leg): 07/11/2018 17:00 2nd (2nd leg): 28/11/2018 13:00 Winner: Chelsea FC
1st(1st leg) FC Midtjylland - Hamilton Academical 2:0 (2:0)
2nd (2nd leg) Hamilton Academical - FC Midtjylland 1:2 (1:0)
1st(1st leg): 07/11/2018 17:30 2nd (2nd leg): 28/11/2018 19:00 Winner: FC Midtjylland