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| 1st(1st leg) | Linfield FC | - | FC Nantes | 0:1 (0:1) | ||
| 2nd (2nd leg) | FC Nantes | - | Linfield FC | 2:0 (0:0) | ||
| 1st(1st leg): 16/09/1980 17:00 | 2nd (2nd leg): 01/10/1980 19:30 | Winner: FC Nantes | ||||
| 1st(1st leg) | ÍBV Vestmannaeyjar | - | TJ Baník Ostrava OKD | 1:1 (1:1) | ||
| 2nd (2nd leg) | TJ Baník Ostrava OKD | - | ÍBV Vestmannaeyjar | 1:0 (1:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: TJ Baník Ostrava OKD | ||||
| 1st(1st leg) | Viking FK | - | Crvena Zvezda | 2:3 (1:0) | ||
| 2nd (2nd leg) | Crvena Zvezda | - | Viking FK | 4:1 (3:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Crvena Zvezda | ||||
| 1st(1st leg) | Trabzonspor | - | Szombierki Bytom | 2:1 (1:0) | ||
| 2nd (2nd leg) | Szombierki Bytom | - | Trabzonspor | 3:0 (1:0) | ||
| 1st(1st leg): 17/09/1980 15:00 | 2nd (2nd leg): 01/10/1980 13:30 | Winner: Szombierki Bytom | ||||
| 1st(1st leg) | Dinamo Tiranë | - | AFC Ajax | 0:2 (0:0) | ||
| 2nd (2nd leg) | AFC Ajax | - | Dinamo Tiranë | 1:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 15:30 | 2nd (2nd leg): 01/10/1980 19:15 | Winner: AFC Ajax | ||||
| 1st(1st leg) | BFC Dynamo | - | APOEL Nikosia | 3:0 (0:0) | ||
| 2nd (2nd leg) | APOEL Nikosia | - | BFC Dynamo | 2:1 (1:0) | ||
| 1st(1st leg): 17/09/1980 16:00 | 2nd (2nd leg): 01/10/1980 19:00 | Winner: BFC Dynamo | ||||
| 1st(1st leg) | Limerick United | - | Real Madrid | 1:2 (0:0) | ||
| 2nd (2nd leg) | Real Madrid | - | Limerick United | 5:1 (2:1) | ||
| 1st(1st leg): 17/09/1980 16:45 | 2nd (2nd leg): 01/10/1980 20:00 | Winner: Real Madrid | ||||
| 1st(1st leg) | CSKA Sofia | - | Nottingham Forest | 1:0 (0:0) | ||
| 2nd (2nd leg) | Nottingham Forest | - | CSKA Sofia | 0:1 (0:1) | ||
| 1st(1st leg): 17/09/1980 17:30 | 2nd (2nd leg): 01/10/1980 18:30 | Winner: CSKA Sofia | ||||
| 1st(1st leg) | Olympiakos Piraeus | - | Bayern München | 2:4 (1:1) | ||
| 2nd (2nd leg) | Bayern München | - | Olympiakos Piraeus | 3:0 (2:0) | ||
| 1st(1st leg): 17/09/1980 17:30 | 2nd (2nd leg): 01/10/1980 19:00 | Winner: Bayern München | ||||
| 1st(1st leg) | Aberdeen FC | - | Austria Wien | 1:0 (1:0) | ||
| 2nd (2nd leg) | Austria Wien | - | Aberdeen FC | 0:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 17:30 | 2nd (2nd leg): 01/10/1980 18:30 | Winner: Aberdeen FC | ||||
| 1st(1st leg) | OPS Oulu | - | Liverpool FC | 1:1 (0:1) | ||
| 2nd (2nd leg) | Liverpool FC | - | OPS Oulu | 10:1 (4:0) | ||
| 1st(1st leg): 17/09/1980 18:00 | 2nd (2nd leg): 01/10/1980 18:30 | Winner: Liverpool FC | ||||
| 1st(1st leg) | Halmstads BK | - | Esbjerg fB | 0:0 (0:0) | ||
| 2nd (2nd leg) | Esbjerg fB | - | Halmstads BK | 3:2 (2:1) | ||
| 1st(1st leg): 17/09/1980 18:00 | 2nd (2nd leg): 01/10/1980 19:00 | Winner: Esbjerg fB | ||||
| 1st(1st leg) | Jeunesse Esch | - | Spartak Moskva | 0:5 (0:3) | ||
| 2nd (2nd leg) | Spartak Moskva | - | Jeunesse Esch | 4:0 (3:0) | ||
| 1st(1st leg): 17/09/1980 18:30 | 2nd (2nd leg): 01/10/1980 17:00 | Winner: Spartak Moskva | ||||
| 1st(1st leg) | Club Brugge KV | - | FC Basel | 0:1 (0:0) | ||
| 2nd (2nd leg) | FC Basel | - | Club Brugge KV | 4:1 (1:1) | ||
| 1st(1st leg): 17/09/1980 19:00 | 2nd (2nd leg): 01/10/1980 19:00 | Winner: FC Basel | ||||
| 1st(1st leg) | Inter | - | FC Universitatea Craiova | 2:0 (1:0) | ||
| 2nd (2nd leg) | FC Universitatea Craiova | - | Inter | 1:1 (1:1) | ||
| 1st(1st leg): 17/09/1980 19:45 | 2nd (2nd leg): 01/10/1980 13:00 | Winner: Inter | ||||
| 1st(1st leg) | Sporting CP | - | Budapest Honved SE | 0:2 (0:0) | ||
| 2nd (2nd leg) | Budapest Honved SE | - | Sporting CP | 1:0 (1:0) | ||
| 1st(1st leg): 17/09/1980 20:30 | 2nd (2nd leg): 01/10/1980 16:30 | Winner: Budapest Honved SE | ||||
