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| 1st(1st leg) | FC La Chaux-de-Fonds | - | Leixões SC | 6:2 (2:1) | ||
| 2nd (2nd leg) | Leixões SC | - | FC La Chaux-de-Fonds | 5:0 (2:0) | ||
| 1st(1st leg): 07/09/1961 | 2nd (2nd leg): 05/10/1961 | Winner: Leixões SC | ||||
| 1st(1st leg) | Dunfermline Athletic | - | St Patrick's Athletic | 4:1 (3:1) | ||
| 2nd (2nd leg) | St Patrick's Athletic | - | Dunfermline Athletic | 0:4 (0:3) | ||
| 1st(1st leg): 12/09/1961 | 2nd (2nd leg): 27/09/1961 | Winner: Dunfermline Athletic | ||||
| 1st(1st leg) | Rapid Wien | - | Spartak Varna | 0:0 (0:0) | ||
| 2nd (2nd leg) | Spartak Varna | - | Rapid Wien | 2:5 (0:2) | ||
| 1st(1st leg): 13/09/1961 | 2nd (2nd leg): 27/09/1961 | Winner: Rapid Wien | ||||
| 1st(1st leg) | Glenavon FC | - | Leicester City | 1:4 (1:3) | ||
| 2nd (2nd leg) | Leicester City | - | Glenavon FC | 3:1 (0:0) | ||
| 1st(1st leg): 13/09/1961 | 2nd (2nd leg): 27/09/1961 | Winner: Leicester City | ||||
| 1st(1st leg) | UA Sedan-Torcy | - | Atlético Madrid | 2:3 (0:3) | ||
| 2nd (2nd leg) | Atlético Madrid | - | UA Sedan-Torcy | 4:1 (3:0) | ||
| 1st(1st leg): 13/09/1961 | 2nd (2nd leg): 27/09/1961 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | Floriana FC | - | Újpesti Dózsa SC | 2:5 (0:3) | ||
| 2nd (2nd leg) | Újpesti Dózsa SC | - | Floriana FC | 10:2 (5:1) | ||
| 1st(1st leg): 17/09/1961 | 2nd (2nd leg): 27/09/1961 | Winner: Újpesti Dózsa SC | ||||
| 1st(1st leg) | Swansea Town | - | SC Motor Jena | 2:2 (1:2) | ||
| 2nd (2nd leg) | SC Motor Jena | - | Swansea Town | 5:1 (2:1) | ||
| 1st(1st leg): 16/10/1961 | 2nd (2nd leg): 18/10/1961 | Winner: SC Motor Jena | ||||
