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| 1st(1st leg) | Vejle BK | - | FC Twente '65 | 0:3 (0:1) | ||
| 2nd (2nd leg) | FC Twente '65 | - | Vejle BK | 4:0 (3:0) | ||
| 1st(1st leg): 01/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: FC Twente '65 | ||||
| 1st(1st leg) | Austria Wien | - | Hajduk Split | 1:1 (0:0) | ||
| 2nd (2nd leg) | Hajduk Split | - | Austria Wien | 0:3 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 02/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: Austria Wien | ||||
| 1st(1st leg) | Real Betis | - | Dinamo Moskva | 0:0 (0:0) | ||
| 2nd (2nd leg) | Dinamo Moskva | - | Real Betis | 3:0 (0:0) | ||
| 1st(1st leg): 02/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: Dinamo Moskva | ||||
| 1st(1st leg) | FC Porto | - | RSC Anderlecht | 1:0 (1:0) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | FC Porto | 3:0 (2:0) | ||
| 1st(1st leg): 02/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: RSC Anderlecht | ||||
