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| 1st(1st leg) | Bayern München | - | Paris Saint-Germain | 1:2 (0:1) | ||
| 2nd (2nd leg) | Paris Saint-Germain | - | Bayern München | 2:2 (1:1, 1:2) aet | ||
| 1st(1st leg): 22/03/2022 17:45 | 2nd (2nd leg): 30/03/2022 20:00 | Winner: Paris Saint-Germain | ||||
| 1st(1st leg) | Real Madrid | - | FC Barcelona | 1:3 (1:0) | ||
| 2nd (2nd leg) | FC Barcelona | - | Real Madrid | 5:2 (1:1) | ||
| 1st(1st leg): 22/03/2022 20:00 | 2nd (2nd leg): 30/03/2022 17:45 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Juventus | - | Olympique Lyon | 2:1 (0:1) | ||
| 2nd (2nd leg) | Olympique Lyon | - | Juventus | 3:1 (2:0) | ||
| 1st(1st leg): 23/03/2022 17:45 | 2nd (2nd leg): 31/03/2022 20:00 | Winner: Olympique Lyon | ||||
| 1st(1st leg) | Arsenal WFC | - | VfL Wolfsburg | 1:1 (0:1) | ||
| 2nd (2nd leg) | VfL Wolfsburg | - | Arsenal WFC | 2:0 (1:0) | ||
| 1st(1st leg): 23/03/2022 20:00 | 2nd (2nd leg): 31/03/2022 17:45 | Winner: VfL Wolfsburg | ||||
