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| 1st(1st leg) | ÍA Akranes | - | 1. FC Köln | 0:4 (0:0) | ||
| 2nd (2nd leg) | 1. FC Köln | - | ÍA Akranes | 6:0 (2:0) | ||
| 1st(1st leg): 16/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | Sliema Wanderers | - | FC Barcelona | 0:2 (0:1) | ||
| 2nd (2nd leg) | FC Barcelona | - | Sliema Wanderers | 1:0 (1:0) | ||
| 1st(1st leg): 16/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Újpesti Dózsa SC | - | Real Sociedad | 1:1 (0:0) | ||
| 2nd (2nd leg) | Real Sociedad | - | Újpesti Dózsa SC | 1:0 (0:0) | ||
| 1st(1st leg): 16/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Real Sociedad | ||||
| 1st(1st leg) | AZ '67 Alkmaar | - | Red Boys Differdange | 6:0 (3:0) | ||
| 2nd (2nd leg) | Red Boys Differdange | - | AZ '67 Alkmaar | 0:4 (0:2) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 30/09/1980 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | Argeș Pitești | - | FC Utrecht | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Utrecht | - | Argeș Pitești | 2:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: FC Utrecht | ||||
| 1st(1st leg) | Ballymena United | - | FC Vorwärts Frankfurt/Oder | 2:1 (0:1) | ||
| 2nd (2nd leg) | FC Vorwärts Frankfurt/Oder | - | Ballymena United | 3:0 (2:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: FC Vorwärts Frankfurt/Oder | ||||
| 1st(1st leg) | TJ Bohemians ČKD Praha | - | Sporting Gijón | 3:1 (1:0) | ||
| 2nd (2nd leg) | Sporting Gijón | - | TJ Bohemians ČKD Praha | 2:1 (1:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: TJ Bohemians ČKD Praha | ||||
| 1st(1st leg) | Dynamo Dresden | - | FK Napredak | 1:0 (0:0) | ||
| 2nd (2nd leg) | FK Napredak | - | Dynamo Dresden | 0:1 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Dynamo Dresden | ||||
| 1st(1st leg) | IF Elfsborg | - | St. Mirren FC | 1:2 (1:1) | ||
| 2nd (2nd leg) | St. Mirren FC | - | IF Elfsborg | 0:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: St. Mirren FC | ||||
| 1st(1st leg) | Grasshopper Club Zürich | - | KB København | 3:1 (1:0) | ||
| 2nd (2nd leg) | KB København | - | Grasshopper Club Zürich | 2:5 (1:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Grasshopper Club Zürich | ||||
| 1st(1st leg) | Hamburger SV | - | FK Sarajevo | 4:2 (3:1) | ||
| 2nd (2nd leg) | FK Sarajevo | - | Hamburger SV | 3:3 (2:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Hamburger SV | ||||
| 1st(1st leg) | Ipswich Town | - | Aris Saloniki | 5:1 (3:0) | ||
| 2nd (2nd leg) | Aris Saloniki | - | Ipswich Town | 3:1 (2:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Ipswich Town | ||||
| 1st(1st leg) | Juventus | - | Panathinaikos | 4:0 (4:0) | ||
| 2nd (2nd leg) | Panathinaikos | - | Juventus | 4:2 (2:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Juventus | ||||
| 1st(1st leg) | 1. FC Kaiserslautern | - | RSC Anderlecht | 1:0 (1:0) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | 1. FC Kaiserslautern | 3:2 (1:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: 1. FC Kaiserslautern | ||||
| 1st(1st leg) | Dinamo Kiev | - | Levski Sofia | 1:1 (1:1) | ||
| 2nd (2nd leg) | Levski Sofia | - | Dinamo Kiev | 0:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Levski Sofia | ||||
| 1st(1st leg) | PSV Eindhoven | - | Wolverhampton Wanderers | 3:1 (1:0) | ||
| 2nd (2nd leg) | Wolverhampton Wanderers | - | PSV Eindhoven | 1:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | Kuopion PS | - | AS Saint-Étienne | 0:7 (0:2) | ||
| 2nd (2nd leg) | AS Saint-Étienne | - | Kuopion PS | 7:0 (3:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | Linzer ASK | - | Radnički Niš | 1:2 (0:1) | ||
| 2nd (2nd leg) | Radnički Niš | - | Linzer ASK | 4:1 (3:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Radnički Niš | ||||
| 1st(1st leg) | Sporting Lokeren | - | Dinamo Moskva | 1:1 (0:1) | ||
| 2nd (2nd leg) | Dinamo Moskva | - | Sporting Lokeren | 0:1 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Sporting Lokeren | ||||
| 1st(1st leg) | 1. FC Magdeburg | - | Moss FK | 2:1 (1:0) | ||
| 2nd (2nd leg) | Moss FK | - | 1. FC Magdeburg | 2:3 (0:2) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: 1. FC Magdeburg | ||||
| 1st(1st leg) | Manchester United | - | Widzew Łódź | 1:1 (1:1) | ||
| 2nd (2nd leg) | Widzew Łódź | - | Manchester United | 0:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Widzew Łódź | ||||
| 1st(1st leg) | FC Porto | - | Dundalk FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Dundalk FC | - | FC Porto | 0:0 (0:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: FC Porto | ||||
| 1st(1st leg) | RWD Molenbeek | - | Torino FC | 1:2 (1:0) | ||
| 2nd (2nd leg) | Torino FC | - | RWD Molenbeek | 2:2 (1:0, 1:2) aet | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Torino FC | ||||
| 1st(1st leg) | Shakhtyor Donetsk | - | Eintracht Frankfurt | 1:0 (1:0) | ||
| 2nd (2nd leg) | Eintracht Frankfurt | - | Shakhtyor Donetsk | 3:0 (2:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Eintracht Frankfurt | ||||
| 1st(1st leg) | Śląsk Wrocław | - | Dundee United | 0:0 (0:0) | ||
| 2nd (2nd leg) | Dundee United | - | Śląsk Wrocław | 7:2 (2:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Dundee United | ||||
| 1st(1st leg) | FC Sochaux | - | Servette FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Servette FC | - | FC Sochaux | 2:1 (0:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: FC Sochaux | ||||
| 1st(1st leg) | Standard Liège | - | CSA Steaua București | 1:1 (1:0) | ||
| 2nd (2nd leg) | CSA Steaua București | - | Standard Liège | 1:2 (1:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Standard Liège | ||||
| 1st(1st leg) | VfB Stuttgart | - | Pezoporikos Larnaca | 6:0 (3:0) | ||
| 2nd (2nd leg) | Pezoporikos Larnaca | - | VfB Stuttgart | 1:4 (0:3) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 24/09/1980 | Winner: VfB Stuttgart | ||||
| 1st(1st leg) | FC Twente | - | IFK Göteborg | 5:1 (2:0) | ||
| 2nd (2nd leg) | IFK Göteborg | - | FC Twente | 2:0 (1:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: FC Twente | ||||
| 1st(1st leg) | Budapesti Vasas | - | Boavista | 0:2 (0:2) | ||
| 2nd (2nd leg) | Boavista | - | Budapesti Vasas | 0:1 (0:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: Boavista | ||||
| 1st(1st leg) | TJ Zbrojovka Brno | - | SK VOEST Linz | 3:1 (2:1) | ||
| 2nd (2nd leg) | SK VOEST Linz | - | TJ Zbrojovka Brno | 0:2 (0:1) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: TJ Zbrojovka Brno | ||||
| 1st(1st leg) | Fenerbahçe | - | PFC Beroe | 0:1 (0:1) | ||
| 2nd (2nd leg) | PFC Beroe | - | Fenerbahçe | 2:1 (1:0) | ||
| 1st(1st leg): 17/09/1980 | 2nd (2nd leg): 01/10/1980 | Winner: PFC Beroe | ||||
