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| 1st(1st leg) | Standard Liège | - | 1. FC Köln | 0:0 (0:0) | ||
| 2nd (2nd leg) | 1. FC Köln | - | Standard Liège | 3:2 (1:1) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | AZ '67 Alkmaar | - | Sporting Lokeren | 2:0 (2:0) | ||
| 2nd (2nd leg) | Sporting Lokeren | - | AZ '67 Alkmaar | 1:0 (1:0) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | AS Saint-Étienne | - | Ipswich Town | 1:4 (1:1) | ||
| 2nd (2nd leg) | Ipswich Town | - | AS Saint-Étienne | 3:1 (0:0) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: Ipswich Town | ||||
| 1st(1st leg) | Grasshopper Club Zürich | - | FC Sochaux | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Sochaux | - | Grasshopper Club Zürich | 2:1 (1:1) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: FC Sochaux | ||||
