| 1. Round | 24/07/2022 | FC Schalke 04 II | - | SV 19 Straelen | 1:0 | ||||
| 2. Round | 31/07/2022 | 1. FC Köln II | - | FC Schalke 04 II | 1:3 |  |
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| 3. Round | 07/08/2022 | FC Schalke 04 II | - | SV Lippstadt 08 | 1:3 |  |
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| 4. Round | 13/08/2022 | SV Rödinghausen | - | FC Schalke 04 II | 2:0 | ||||
| 5. Round | 20/08/2022 | Fortuna Köln | - | FC Schalke 04 II | 0:0 | ||||
| 6. Round | 28/08/2022 | FC Schalke 04 II | - | 1. FC Kaan-Marienborn | 1:2 | ||||
| 7. Round | 03/09/2022 | Rot-Weiß Oberhausen | - | FC Schalke 04 II | 1:3 | |
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| 8. Round | 11/09/2022 | FC Schalke 04 II | - | 1. FC Düren | 4:1 | ||||
| 9. Round | 17/09/2022 | Fortuna Düsseldorf II | - | FC Schalke 04 II | 2:4 | ||||
| 11. Round | 08/10/2022 | Wuppertaler SV | - | FC Schalke 04 II | 1:4 | |
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| 12. Round | 15/10/2022 | FC Schalke 04 II | - | Rot Weiss Ahlen | 2:2 | ||||
| 13. Round | 23/10/2022 | SG Wattenscheid 09 | - | FC Schalke 04 II | 2:1 | ||||
| 14. Round | 29/10/2022 | FC Schalke 04 II | - | SC Wiedenbrück | 1:1 | |
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| 16. Round | 11/11/2022 | FC Schalke 04 II | - | Alemannia Aachen | 0:0 | ||||
| 17. Round | 18/11/2022 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 1:1 | |
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| 19. Round | 02/12/2022 | FC Schalke 04 II | - | 1. FC Köln II | 5:0 |
Romania
Germany