| 1. Round | 14/08/2021 | FC-Astoria Walldorf | - | FC Gießen | 0:1 | ||||
| 2. Round | 21/08/2021 | FC Gießen | - | 1. FSV Mainz 05 II | 0:1 | ||||
| 3. Round | 24/08/2021 | TSV Schott Mainz | - | FC Gießen | 1:0 | ||||
| 4. Round | 28/08/2021 | FC Gießen | - | FK Pirmasens | 0:1 |  |
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| 5. Round | 04/09/2021 | Bahlinger SC | - | FC Gießen | 2:0 | ||||
| 6. Round | 11/09/2021 | FC Gießen | - | TSG Balingen | 3:1 | ||||
| 7. Round | 14/09/2021 | VfR Aalen | - | FC Gießen | 1:0 | ||||
| 11. Round | 02/10/2021 | FC Gießen | - | VfB Stuttgart II | 2:1 | ||||
| 12. Round | 09/10/2021 | FSV Frankfurt | - | FC Gießen | 2:2 | ||||
| 13. Round | 16/10/2021 | FC Gießen | - | FC 08 Homburg | 0:2 | ||||
| 21. Round | 05/12/2021 | 1. FSV Mainz 05 II | - | FC Gießen | 2:0 | ||||
| 22. Round | 11/12/2021 | FC Gießen | - | TSV Schott Mainz | 3:0 | ||||
| 23. Round | 18/12/2021 | FK Pirmasens | - | FC Gießen | 2:1 | ||||
| 32. Round | 05/04/2022 | FC 08 Homburg | - | FC Gießen | 0:0 | ||||
| 33. Round | 09/04/2022 | FC Gießen | - | SV 07 Elversberg | 0:2 | |
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| 30. Round | 13/04/2022 | VfB Stuttgart II | - | FC Gießen | 1:0 | |
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| 34. Round | 16/04/2022 | Kickers Offenbach | - | FC Gießen | 2:0 | ||||
| 37. Round | 07/05/2022 | FC Gießen | - | 1899 Hoffenheim II | 1:2 | ||||
| 38. Round | 14/05/2022 | Hessen Kassel | - | FC Gießen | 3:0 |
Germany
Congo DR