| 2. Round | 21/08/2021 | KFC Uerdingen 05 | - | Bonner SC | 1:3 | ||||
| 3. Round | 25/08/2021 | KFC Uerdingen 05 | - | SC Wiedenbrück | 2:3 |  |
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| 5. Round | 04/09/2021 | KFC Uerdingen 05 | - | Alemannia Aachen | 0:0 | ||||
| 6. Round | 11/09/2021 | Bor. Mönchengladbach II | - | KFC Uerdingen 05 | 0:0 | ||||
| 10. Round | 02/10/2021 | Rot Weiss Ahlen | - | KFC Uerdingen 05 | 1:0 | ||||
| 7. Round | 06/10/2021 | KFC Uerdingen 05 | - | Sportfreunde Lotte | 2:0 | ||||
| 11. Round | 09/10/2021 | KFC Uerdingen 05 | - | Rot-Weiss Essen | 0:11 | ||||
| 13. Round | 23/10/2021 | KFC Uerdingen 05 | - | Wuppertaler SV | 0:2 | |
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| 15. Round | 06/11/2021 | KFC Uerdingen 05 | - | Fortuna Düsseldorf II | 1:1 | ||||
| 17. Round | 20/11/2021 | KFC Uerdingen 05 | - | Preußen Münster | 0:1 | ||||
| 18. Round | 26/11/2021 | FC Schalke 04 II | - | KFC Uerdingen 05 | 4:1 | ||||
| 19. Round | 04/12/2021 | KFC Uerdingen 05 | - | SV Lippstadt 08 | 1:3 |
Germany
Ghana