| 1. Round | 14/08/2021 | Rot-Weiß Oberhausen | - | KFC Uerdingen 05 | 6:0 |  |
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| 2. Round | 21/08/2021 | KFC Uerdingen 05 | - | Bonner SC | 1:3 | ||||
| 3. Round | 25/08/2021 | KFC Uerdingen 05 | - | SC Wiedenbrück | 2:3 | ||||
| 4. Round | 28/08/2021 | 1. FC Köln II | - | KFC Uerdingen 05 | 8:2 | ||||
| 5. Round | 04/09/2021 | KFC Uerdingen 05 | - | Alemannia Aachen | 0:0 | |
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| 6. Round | 11/09/2021 | Bor. Mönchengladbach II | - | KFC Uerdingen 05 | 0:0 | |
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| 8. Round | 18/09/2021 | FC Wegberg-Beeck | - | KFC Uerdingen 05 | 1:1 | |
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| 17. Round | 20/11/2021 | KFC Uerdingen 05 | - | Preußen Münster | 0:1 | ||||
| 18. Round | 26/11/2021 | FC Schalke 04 II | - | KFC Uerdingen 05 | 4:1 | ||||
| 19. Round | 04/12/2021 | KFC Uerdingen 05 | - | SV Lippstadt 08 | 1:3 | |
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| 23. Round | 29/01/2022 | KFC Uerdingen 05 | - | 1. FC Köln II | 2:2 |
Belgium
Congo DR